Omeprazole OTC Bests Lansoprazole OTC for Gastric Acid Control
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In one of the largest crossover studies of its kind to date, nonprescription omeprazole (omeprazole magnesium 20.6 mg) was found to be significantly better than nonprescription lansoprazole (lansoprazole 15 mg) with respect to 24-hour gastric acid suppression.
A total of 40 healthy volunteers participated in the single-center, randomized, double-blind study. Participants received a daily dose of either omeprazole magnesium 20.6 mg or lansoprazole 15 mg before breakfast during each of three dosing periods, in one of two treatment sequences (ABB or BAA). All participants underwent 24-hour gastric pH monitoring on dosing day 5 during each period; the primary efficacy variable was the percentage of time intragastric pH was greater than 4.0.
The mean percentage of time that intragastric pH was greater than 4.0 over 24 hours was significantly greater for omeprazole (45.7%) than for lansoprazole (36.8%). The absolute mean difference between treatments was 8.9% (standard error 2.1%), and the mean relative percentage difference was 24.2%.
Aliment Pharmacol Ther. 2010;31:846-51.